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sparsentan will lower the extent or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and lowers efficacy relevant to these substrates.modafinil will lower the extent or influence of mavacamten by influencing hepatic/intestinal enzyme CYP